Melanotan 1 (MT-1)

also known as: Afamelanotide, CUV1647, Scenesse

SkinImmuneintermediateSubQ

Half-life: ~1 hour (implant form: weeks)

About

Melanotan 1 (MT-1 / Afamelanotide) is a synthetic analog of α-MSH (alpha-melanocyte-stimulating hormone) that stimulates melanin production in the skin. Unlike MT-2, it has minimal central nervous system activity, making it safer with fewer sexual side effects. It is FDA-approved (as Scenesse) for erythropoietic protoporphyria (EPP).

Mechanism of Action

Binds melanocortin 1 receptor (MC1R) on melanocytes, stimulating the production of eumelanin (dark/brown melanin) and providing UV protection through increased pigmentation. Also has anti-inflammatory effects via MC3R and MC4R.

Primary Benefits

Skin tanning without UV exposure
Photoprotection (EU/AU clinical use)
Anti-inflammatory skin effects
No significant sexual side effects (unlike MT-2)
FDA-approved indication (EPP)

Side Effects & Considerations

Facial flushing
Nausea (transient)
Yawning
Temporary darkening of existing moles (monitor)
Fatigue

Research Notes

Approved by EMA (2014) as Scenesse for prevention of phototoxicity in adults with EPP. Clinically proven for photoprotection in that population.

Stacking Guide

Synergistic Stacks

GHK-Cu

GHK-Cu provides skin collagen support alongside MT-1's melanin production for comprehensive skin health.

Redundant / Avoid Together

Melanotan 2 (MT-2)

MT-2 has all the effects of MT-1 plus sexual/appetite effects — they target the same melanocortin receptors and should not be combined.

Complementary Cycles

None listed.

Storage & Reconstitution

Storage

Refrigerate at 2–8°C (36–46°F). Protect from light.

Reconstitution

Reconstitute with bacteriostatic water.

Goals Addressed

Skin Health

Quick Stats

Half-Life: ~1 hour (implant form: weeks)
Admin Routes: SubQ
Experience Level: intermediate

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