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also known as: Copper peptide GHK, Glycyl-histidyl-lysine copper, Copper tripeptide-1
Half-life: Short plasma half-life; tissue binding extends effects
GHK-Cu is a naturally occurring copper-chelating tripeptide (Gly-His-Lys) found in human plasma, saliva, and urine. It is one of the most thoroughly studied peptides for skin rejuvenation, wound healing, and anti-aging, with over 50 years of published research. Plasma levels decline significantly with age.
Mechanism of Action
Copper-bound GHK activates over 4,000 genes related to tissue remodeling, antioxidant defense, anti-inflammatory signaling, and neurogenesis. Stimulates collagen, elastin, and glycosaminoglycan synthesis. Activates ubiquitin-proteasome degradation of damaged proteins.
Discovered by Loren Pickart in 1973 (University of California, San Francisco). Shown to activate genes associated with all major hallmarks of skin aging. Highly cited in wound healing and dermatology literature.
AHK-Cu targets hair follicles specifically; GHK-Cu provides broader collagen and wound healing — synergistic copper peptide pair.
Snap-8 reduces muscle contraction-related wrinkles (expression lines); GHK-Cu rebuilds the dermal collagen matrix beneath.
BPC-157 drives angiogenesis at healing sites; GHK-Cu provides the collagen remodeling and anti-fibrotic action.
Epithalon addresses cellular aging; GHK-Cu addresses the extracellular matrix aging — comprehensive anti-aging duo.
None listed.
Alternate GHK-Cu (broader healing) and AHK-Cu (hair focus) cycles for comprehensive cosmetic results.
Storage
Refrigerate. Protect from light and heat.
Reconstitution
Often supplied as topical solution or lyophilized for injection.