Klotho Derived Peptide 1

also known as: KL1, Klotho fragment, αKlotho peptide

Anti-AgingCognitiveadvancedSubQIntramuscular

Half-life: Unknown for injected fragment

About

Klotho Derived Peptide 1 (KL1) is a fragment of the α-Klotho protein, an aging-suppressor protein encoded by the KL gene. Blood levels of α-Klotho decline with age and are inversely correlated with cardiovascular disease, cognitive decline, and mortality. KL1 has shown cognitive improvements in aging mice at very low doses.

Mechanism of Action

The KL1 domain of α-Klotho modulates FGF23/FGFR signaling, improves synaptic plasticity via GluN2B-containing NMDA receptors, and exerts antioxidant and anti-inflammatory effects in the brain and kidneys.

Primary Benefits

Cognitive improvement and memory enhancement
Synaptic plasticity enhancement
Potential anti-aging effects
Kidney protective properties
Cardiovascular risk reduction
Neuroprotection

Side Effects & Considerations

Very limited human data
Generally well tolerated in animal studies
Unknown long-term effects

Research Notes

Dubal et al. (Cell, 2014) showed systemic klotho elevation via gene injection improved cognitive function in young and aging mice at 10% elevation. Leon et al. (2023) demonstrated KL1 fragment improves working memory in aged mice.