Dihexa

also known as: PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

CognitiveNootropicadvancedSublingualSubQOralTopical

Half-life: Long — estimated days due to tight receptor binding

About

Dihexa is a potent nootropic peptide derived from angiotensin IV. It is one of the most powerful known cognitive enhancers in animal models, reported to be approximately 7 orders of magnitude more potent than BDNF at promoting synapse formation. It acts through the HGF/Met pathway to promote neuroplasticity.

Mechanism of Action

Potentiates HGF (hepatocyte growth factor) binding to its receptor c-Met, dramatically upregulating synaptogenesis, neuronal survival, and memory consolidation pathways in the hippocampus and cortex.

Primary Benefits

Powerful memory improvement
Enhanced learning ability
Synapse formation and neuroplasticity
Potential reversal of cognitive decline
Long-lasting cognitive effects (weeks after a single dose)

Side Effects & Considerations

Limited human safety data
Potential pro-proliferative effects (theoretical cancer concern at very high doses)
Headache
Irritability in some users
Effects persist long after dosing — dose conservatively

Research Notes

Published in PNAS by Joseph Harding et al. (2013). Animal models show reversal of memory deficits from hippocampal damage. No human clinical trials completed.

Stacking Guide

Synergistic Stacks

Semax

Semax raises BDNF acutely; Dihexa potentiates HGF/Met for longer-term synaptogenesis — different but complementary neurotrophin pathways.

Selank

Selank provides anxiolytic and memory enhancement via GABA/serotonin modulation alongside Dihexa's structural synaptic work.

NAD+

NAD+ restores neuronal energy metabolism, supporting the energy-demanding synapse formation Dihexa promotes.

Redundant / Avoid Together

None listed.

Complementary Cycles

Cortagen

Cortagen provides cortical neuron bioregulation; use in alternating cycles with Dihexa for comprehensive nootropic coverage.

PE 22-28

PE 22-28 offers antidepressant and synaptic signaling effects; alternate cycles with Dihexa for broad cognitive support.

Storage & Reconstitution

Storage

Store at room temperature if powder. Refrigerate solutions.

Reconstitution

Dissolve in DMSO for topical use or in saline/water for SubQ.

Goals Addressed

Mental Performance
Anti-Aging
Longevity

Quick Stats

Half-Life: Long — estimated days due to tight receptor binding
Admin Routes: Sublingual, SubQ, Oral, Topical
Experience Level: advanced

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