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also known as: Cortex bioregulator, Brain cortex peptide
Half-life: Unknown; likely short
Cortagen is a tetrapeptide bioregulator derived from brain cortex tissue, developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is designed to maintain and restore neuronal function in the cerebral cortex, with applications in cognitive decline, aging, and neurological conditions.
Mechanism of Action
Penetrates the blood-brain barrier and acts as a chromatin-binding peptide in cortical neurons, upregulating genes involved in neurotrophic factor production and neuronal survival.
Dihexa powerfully stimulates HGF/Met for long-term synaptogenesis; Cortagen supports neuronal survival and cortical gene expression.
Pinealon targets the pineal gland and sleep/circadian regulation; Cortagen targets cortical neurons — complementary brain bioregulators.
Semax acutely raises BDNF; Cortagen provides longer-term cortical gene regulation support.
None listed.
NAD+ restores neuronal energy metabolism; Cortagen restores gene expression — run them in sequence.
Storage
Refrigerate at 2–8°C (36–46°F).
Reconstitution
Reconstitute with bacteriostatic water.