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also known as: NNC 26-0161
Half-life: ~2 hours
Ipamorelin is a highly selective, pentapeptide GH secretagogue that mimics ghrelin to stimulate GH release from the pituitary. It is considered the "cleanest" GH-releasing peptide because it selectively triggers GH without significantly elevating cortisol, prolactin, or ACTH — making it the preferred entry point for GH peptide protocols.
Mechanism of Action
Binds GHS-R1a (ghrelin receptor) on pituitary somatotrophs, triggering GH pulse release. High selectivity means minimal stimulation of the adrenal/stress axis compared to GHRP-2 or GHRP-6.
The classic GH stack — GHRH + GHRP for dramatically amplified GH pulse.
Sermorelin (shorter GHRH analog) + Ipamorelin for a milder, more natural GH protocol.
Tesamorelin + Ipamorelin for visceral fat-specific GH protocol.
MK-677 provides continuous GH elevation; Ipamorelin adds pulsatile peaks on top.
GHRP-2 acts on the same receptor — pick one GH secretagogue GHRP, not both.
GHRP-6 acts on the same receptor — redundant with Ipamorelin.
This blend already contains Ipamorelin.
Use Ipamorelin for long-term clean GH cycles; reserve GHRP-2 for short high-intensity cycles needing stronger GH stimulus.
Storage
Refrigerate at 2–8°C (36–46°F) after reconstitution.
Reconstitution
Reconstitute with bacteriostatic water; 2 mL per 5 mg vial.