Sermorelin

Sermorelin is a synthetic analog of the first 29 amino acids of endogenous GHRH (growth hormone-releasing hormone). It is the oldest GHRH analog in clinical use and was previously FDA-approved for pediatric GH deficiency. It stimulates the pituitary gland to produce GH naturally, preserving pulsatile release and pituitary responsiveness.

• Natural GH pulse stimulation
• Improves body composition over time
• Sleep quality improvement
• Anti-aging effects
• Gentler than newer GHRH analogs — good entry point
• Preserves pituitary function

• Facial flushing
• Water retention
• Headache
• Injection site reactions
• Dizziness

Originally FDA-approved as Geref for pediatric GH deficiency diagnosis. Withdrawn from US market in 2008 but widely available as compounded peptide. Extensive safety record from clinical use.